Although there is an established need for supplementation, most magnesium compounds available on the market have low bioavailability and do not lead to increased magnesium levels in the brain because they cannot cross the blood–brain barrier easily. After adjusting for multiple confounding variables, they found that total magnesium was independently associated with significantly higher global cognitive scores. A study based on data from the National Health and Nutrition Survey (NHANES) between 20 included 2508 participants aged 60 years and older. For example, test anxiety, related to exposure to stressful exam conditions, increases urinary Mg excretion, resulting in a partial reduction in serum Mg levels. A relationship between Mg and anxiety has also been identified. Higher intake of Mg has been associated with lower depression symptoms. Mg supplementation has been shown to improve symptoms of migraine headaches, Alzheimer’s disease, stroke and to have a beneficial effect on subjective anxiety in subjects prone to mental stress. Therefore, supplementation may be warranted. For example, the average intake of dietary magnesium was reported to be 205 mg/day, in 2373 adults from Guangxi, China, of both sexes. Despite an abundance in the food supply, intake of Mg in the Chinese population has been shown to be below the 330 mg/day recommended by the China Nutrition Society.
Mg is abundant in the food supply and can be found in foods such as grains, cereals and dark leaves, including spinach and cabbage. Magnesium (Mg) is the second-most abundant intracellular mineral, and it is required as a cofactor for over 300 enzymatic reactions and is, thus, necessary for the biochemical functioning of numerous metabolic pathways in the body, including energy generation in every cell, protein production, gene regulation, bone and teeth maintenance, as well as the proper functioning of the brain and nervous systems. Results indicated significant benefits of Magtein ®PS in improving memory and cognition in healthy Chinese adults. The older participants showed more improvement than younger participants. Subjects receiving Magtein ®PS showed significant improvements over the control group in all five subcategories of “The Clinical Memory Test” as well as the overall memory quotient scores. “The Clinical Memory Test”, the standard test commonly used in Chinese hospitals and academic institutes for cognitive evaluation, was administered before and 30 days after subjects received the supplement. Subjects were randomly assigned to receive either Magtein ®PS or placebo (starch) capsules, at a dose of 2 g/day. In this double-blind, placebo-controlled study, Magtein ®PS, a magnesium L-threonate (Magtein ®)- and phosphatidylserine-based formulation additionally containing vitamins C and D, was tested for its cognitive benefits in 109 healthy Chinese adults aged 18–65 years. In 2010, a novel magnesium compound, magnesium L-threonate (Magtein ®) was identified and was shown to raise the magnesium levels in the brain and neurons effectively. Magnesium supplements mostly have low bioavailability, except magnesium L-threonate. This article has been authored by Lauren Lehmkuhl and peer reviewed by Mikaela Frame and Sinead Adedipe.Magnesium is one of the most abundant essential minerals in the body. If your goal is to increase your magnesium levels the quickest, magnesium glycinate may be best for you, but if your goal is to improve cognitive health, magnesium L-threonate might be a good option for you as well. Magnesium L-threonate has its own benefits! It's chelated to a metabolite of vitamin C, which allows it to cross the blood-brain barrier to help improve cognitive health. Since one of the main goals of Vessel is to help people correct deficiencies quickly, we want to recommend the form of nutrients that may help them the most. This makes the compound very stable for absorption and is less likely to cause gastrointestinal symptoms like a laxative effect. The reason magnesium glycinate is well absorbed is that it is chelated to amino acid (glycine). We like to recommend magnesium glycinate because it is one of the most absorbable forms of magnesium and is best for relaxation and sleep quality which can aid in managing cortisol levels.
There are many different forms of magnesium that may be beneficial for different areas of health.
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